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AboutStudy Design1L study design2L+ study designEfficacy1L overall efficacy1L CNS efficacy1L 36-month overall efficacy1L 36-month CNS efficacy2L+ efficacySafetyPooled Safety: all lines1L safety2L+ safetyDosing & Therapy ManagementDosingTherapy managementResourcesPrescribing InformationEventsMaterialsVideos
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First-line overall efficacyLORVIQUA significantly improved progression-free survival vs crizotinib1,2 Progression-free survival by BICR (ITT population, N=296)1,2

Data cutoff: 20 March 2020.2
Adapted from Shaw AT et al. N Engl J Med. 2020;383:2018-29.2

  • Patients receiving LORVIQUA experienced longer PFS vs crizotinib, irrespective of baseline patient and disease characteristics1,2
  • At data cutoff, OS data were not mature2
Progression-free survival (BICR assessed): subgroup analysis3

Data cutoff: 20 March 2020.2
Adapted from Shaw AT et al. N Engl J Med (Suppl). 2020;383:2018-29.3

This graph depicts prespecified exploratory subgroup analyses from the CROWN trial. Small patient numbers can be a limitation of subgroup analyses. These results are presented for descriptive purposes and should not be interpreted as a demonstration of efficacy in any particular subgroup.

Improved tumour response with LORVIQUA vs crizotinib1,2 ORR (ITT population, N=296)a

aDefined as confirmed complete response or partial response as assessed by BICR.1,2 
Data cutoff: 20 March 2020.2

  • Median DoR: Not estimable (95% Cl, NE-NE) with LORVIQUA vs 11 months (95% Cl, 9-13) with crizotinib1
  • Response duration ≥12 months: 70% with LORVIQUA vs 27% with crizotinib2
BICR=blinded independent central review; CNS=central nervous system; DoR=duration of response; ECOG PS=Eastern Cooperative Oncology Group performance status; HR=hazard ratio; ITT=intention to treat; NE=not estimable; ORR=objective response rate; OS=overall survival; PFS=progression-free survival.ReferencesReferences:Lorviqua Prescribing Information. https://labeling.pfizer.com/ShowLabeling.aspx?id=17716. Accessed on 30 May 2023.Shaw AT, Bauer TM, de Marinis F, et al; CROWN Trial Investigators. First-line lorlatinib or crizotinib in advanced ALK-positive lung cancer. N Engl J Med. 2020;383(21):2018-2029.Shaw AT, Bauer TM, de Marinis F, et al; CROWN Trial Investigators. First-line lorlatinib or crizotinib in advanced ALK-positive lung cancer [supplementary appendix]. N Engl J Med. 2020;383(21):2018-2029. Efficacy
LORVIQUA safety profile
 Review the safety First-line LORVIQUA Case Study Video

Todd Bauer, MD, presents a case study of a patient with ALK+ NSCLC receiving LORVIQUA in the first-line setting.

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PP-LOR-GLB-0023

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