ZITHROMAX | Pharyngitis/Tonsillitis | PfizerPro XX (country)

Administration

Pathogens

Epidemiology

Efficacy

Tab Number 5

Administration

Adults¹
500 mg once daily for 3 days, or an alternative of 500 mg on Day 1, then 250 mg daily on Days 2-5

Pediatrics¹
Single dose of 10 mg/kg or 20 mg/kg for 3 days

ZITHROMAX should be given as a single daily dose¹
ZITHROMAX tablets and suspension can be taken with or without food¹
ZITHROMAX tablets should only be administered to children weighing more than 45 kg¹
Administration of ZITHROMAX suspension should follow adults dosage for children weighing more than 45 kg¹

Resources

Pediatrics: How to Properly Administer ZITHROMAX®

Watch now

Renal Impairment¹

No dose adjustment is necessary in patients with mild to moderate renal impairment (glomerular filtration rate [GFR] of 10–80 mL/min). Caution should be exercised when ZITHROMAX is administered to patients with severe renal impairment (GFR <10 mL/min)

Hepatic Impairment¹

The same dosage as in patients with normal hepatic function may be used in patients with mild to moderate hepatic impairment

Pathogens

Main Bacterial Pathogens

Group A streptococcal pharyngitis accounts for 25–40% of cases in children and for 10–25% in adults²
Streptococcus pyogenes is responsible for 5–30% of cases of acute pharyngitis in the US and is more common in children than adults³

Efficacy

ZITHROMAX – A single daily dose delivers high success rates in upper respiratory tract infections⁴

Clinical Success Rate Following Treatment With Azithromycin in Adults >18 Years

Adapted from Donde et al. 2014⁴

Clinical Success Rate Among Children and Adolescents Age ≤18 years

Adapted from Donde et al. 2014⁴

Donde et al. 2014⁴

An open-label, prospective, multicenter, non-interventional study to assess the safety and tolerability of azithromycin in acute bacterial upper respiratory tract infections (URTIs)
Primary objective: assess the effectiveness of azithromycin in acute bacterial URTIs
In general, in children a total single dose of 30 mg/kg was given over a period of 3–5 days; the maximum recommended total dose of azithromycin was 1,500 mg
Overall success rate for clinical outcome in the evaluable (278 of 410) population was 98.92%

ZITHROMAX – Once daily over 3 days is as effective as 10 days of pen-V every 6 hours in acute pharyngitis or tonsillitis⁵

Clinical and Bacteriological Response at the End of Therapy (Day 9-11) in Children Aged 2-12 Years with GABHS Isolated at Baseline⁵

Adapted from Hamil et al. 1993⁵

Hamill et al. 1993⁵

A multicenter, randomized study of single-dose azithromycin for 3 days and penicillin V (pen-V) qid for 10 days in the treatment of children with acute pharyngitis or tonsillitis caused by group A beta-hemolytic streptococci (GABHS)
Cure or improvement was 98% and 100% for azithromycin and pen-V treated patients, respectively. At Day 11, bacterial eradication was 95% (39/41) with azithromycin, 38 (93%) were clinically cured, and one patient (2%) relapsed. In the pen-V group, 42/44 (95%) had GABHS eradicated, with 41 (93%) clinically cured and three patients (7%) improved
Once-daily azithromycin for 3 days is clinically equivalent to 10 days of pen-V four times daily in the treatment of children with acute pharyngitis or tonsillitis caused by GABHS