This site is intended only for healthcare professionals residing in Malaysia




Log Out Our medicinesTherapy AreaExplore contentExplore contentEventsDownloadable materialsVideosLet’s connectLet's ConnectContact usPfizer medical information



RTIs & Acute Otitis MediaUpper Respiratory Tract Infections (Upper RTIs)Acute Bacterial SinusitisPharyngitis/TonsillitisAcute Otitis MediaAcute Otitis MediaLower Respiratory Tract Infections (Lower RTIs)Community-Acquired PneumoniaAcute Bacterial Exacerbation of Chronic BronchitisSTIsSexually Transmitted Infections (STIs)Infections by Chlamydia trachomatisInfections by Neisseria gonorrhoeaeChancroid/Genital Ulcers MenSSTIsSkin and Soft-Tissue Infections (SSTIs)Uncomplicated Skin and Soft-Tissue InfectionsSafetySafetySafetyAdditional InformationAdditional InformationIndication and SusceptibilityFormulationsMode of ActionReconstitution of Powder for Oral Suspension for PediatricsPediatric AdministrationResourcesResourcesPrescribing InformationEventsMaterialsVideos

RTIs & Acute Otitis Media  |  Upper Respiratory Tract Infections | Pharyngitis/Tonsillitis






Tab Number 5


500 mg once daily for 3 days, or an alternative of 500 mg on Day 1, then 250 mg daily on Days 2-5

Single dose of 10 mg/kg or 20 mg/kg for 3 days

  • ZITHROMAX should be given as a single daily dose1
  • ZITHROMAX tablets and suspension can be taken with or without food1
  • ZITHROMAX tablets should only be administered to children weighing more than 45 kg1
  • Administration of ZITHROMAX suspension should follow adults dosage for children weighing more than 45 kg1
Resources Pediatrics: How to Properly Administer ZITHROMAX® Watch nowLoadingRenal Impairment1

No dose adjustment is necessary in patients with mild to moderate renal impairment (glomerular filtration rate [GFR] of 10–80 mL/min). Caution should be exercised when ZITHROMAX is administered to patients with severe renal impairment (GFR <10 mL/min)

Hepatic Impairment1

The same dosage as in patients with normal hepatic function may be used in patients with mild to moderate hepatic impairment

PathogensMain Bacterial Pathogens
  • Group A streptococcal pharyngitis accounts for 25–40% of cases in children and for 10–25% in adults2
  • Streptococcus pyogenes is responsible for 5–30% of cases of acute pharyngitis in the US and is more common in children than adults3
EfficacyZITHROMAX – A single daily dose delivers high success rates in upper respiratory tract infections4

Clinical Success Rate Following Treatment With Azithromycin in Adults >18 Years

Adapted from Donde et al. 20144

Clinical Success Rate Among Children and Adolescents Age ≤18 years

Adapted from Donde et al. 20144

Donde et al. 20144
  • An open-label, prospective, multicenter, non-interventional study to assess the safety and tolerability of azithromycin in acute bacterial upper respiratory tract infections (URTIs)
  • Primary objective: assess the effectiveness of azithromycin in acute bacterial URTIs
  • In general, in children a total single dose of 30 mg/kg was given over a period of 3–5 days; the maximum recommended total dose of azithromycin was 1,500 mg
  • Overall success rate for clinical outcome in the evaluable (278 of 410) population was 98.92%
ZITHROMAX – Once daily over 3 days is as effective as 10 days of pen-V every 6 hours in acute pharyngitis or tonsillitis5

Clinical and Bacteriological Response at the End of Therapy (Day 9-11) in Children Aged 2-12 Years with GABHS Isolated at Baseline5

Adapted from Hamil et al. 19935

Hamill et al. 19935
  • A multicenter, randomized study of single-dose azithromycin for 3 days and penicillin V (pen-V) qid for 10 days in the treatment of children with acute pharyngitis or tonsillitis caused by group A beta-hemolytic streptococci (GABHS)
  • Cure or improvement was 98% and 100% for azithromycin and pen-V treated patients, respectively. At Day 11, bacterial eradication was 95% (39/41) with azithromycin, 38 (93%) were clinically cured, and one patient (2%) relapsed. In the pen-V group, 42/44 (95%) had GABHS eradicated, with 41 (93%) clinically cured and three patients (7%) improved
  • Once-daily azithromycin for 3 days is clinically equivalent to 10 days of pen-V four times daily in the treatment of children with acute pharyngitis or tonsillitis caused by GABHS
TitleZITHROMAX is contraindicated in patients with a known hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotic, or to any of the excipients.1
As with any antibiotic preparation, observation for signs of superinfection with non-susceptible organisms including fungi is recommended. Clostridium difficile associated diarrhea has been reported with azithromycin, and may range in severity from mild diarrhea to fatal colitis.1
You might also be interested in...Upper Respiratory Tract Infections Acute Bacterial Sinusitis Find out more LoadingAcute Otitis Media Acute Otitis Media Find out more LoadingResources ZITHROMAX® Mode of Action Watch now LoadingReferences:Pfizer Malaysia ZITHROMAX Prescribing Information. Available at: Accessed January 2024.Agence Française de Sécurité Sanitaire des Produits de Santé. CMI. 2003;9:1162–78.Anjos L, et al. Rev Soc Bras Med Trop. 2014;47(4):409–13.Donde S, et al. Indian J Otolaryngol Head Neck Surg. 2014;66(Suppl. 1):S225–S230.Hamill J. J Antimicrob Chemother. 1993;31(Suppl. E):89–94
Upper Respiratory Tract Infections  ZITHROMAX® Safety Information Find out more Loading
PfizerPro AccountPfizerPro Account

To access further materials, resources and receive communication about medicines and vaccines promoted by Pfizer.

Sign inRegisterAccountSign Out

This site is intended only for healthcare professionals residing in Malaysia. If you are a member of public wishing to access information on a specific medicine, please consult with your doctor.


This website is brought to you by
Pfizer (Malaysia) Sdn Bhd 197801003134
Level 10 & 11, Wisma Averis (Tower 2),
Bangsar South, No. 8, Jalan Kerinchi, 
59200 Kuala Lumpur, Malaysia.
Tel: 603-2281 6000 
Fax: 603-2281 6388 

Copyright © 2023 Pfizer Limited. All rights reserved.


You are now leaving the PfizerPro Malaysia website
You are now being directed to a third-party website. It is clarified that Pfizer will not be collecting, storing, or accessing any personal information shared by you on the third-party website and Pfizer's Privacy Policy will not apply. Pfizer does not review or control or endorse the content of the third-party website and shall have no liability / assumes no responsibility for any issues arising out of you accessing the third-party website, accuracy of the information, practices, and standards of the third-party website. You will be bound by the Privacy Policy and Terms of Use of the third-party website and be solely responsible for your interactions with that website.
     PP-UNP-MYS-0077 - 10FEB2023