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Undesirable effects
Gastrointestinal disorders
- Diarrhoea
Infections and infestations
- Candida infection
Blood and lymphatic system disorders
- Thrombocytopenia anaemia
Psychiatric disorders
- Insomnia
Nervous system disorders
- Headache
Gastrointestinal disorders
- Abdominal pain, vomiting, constipation, nausea, dyspepsis
Skin and subcutaneous tissue disorders
- Rash, pruritus
General disorders and administration site conditions
- Pyrexia, injection site reaction
Investigations
- Alanine aminotransferase increased, aspartate aminotransferase increased, protein total decreased, blood albumin decreased, Coombs direct test positive, blood creatinine increased, blood alkaline phosphatase increased, blood urea increased, activated partial thromboplastin time prolonged
Blood and lymphatic system disorders
- Leukopenia
Metabolism and nutrition disorders
- Hypokalaemia
Nervous system disorders
- Seizures
Vascular disorders
- Hypotension, phlebitis, thrombophlebitis, flushing
Skin and subcutaneous tissue disorders
- Erythema multiforme, urticaria, rash maculo-papular
Musculoskeletal and connective tissue disorders
- Arthralgia, myalgia
General disorders and administration site conditions
- Chills
Investigations
- Blood glucose decreased, blood bilirubin increased, prothrombin time prolonged
Infections and infestations
- Pseudomembranous colitis
Blood and lymphatic system disorders
- Agranulocytosis
Respiratory, thoracic and mediastinal disorders
- Epistaxis
Gastrointestinal disorders
- Stomatitis
Skin and subcutaneous tissue disorders
- Toxic epidermal necrolysis
Blood and lymphatic system disorders
- Pancytopenia, neutropenia, haemolytic anaemia, thrombocytosis, eosinophilia
Immune system disorders
- Anaphylactoid shock, anaphylactic shock, anaphylactoid reaction, anaphylactic reaction, hypersensitivity kounis syndrome
Psychiatric disorders
- Delirium
Respiratory, thoracic and mediastinal disorders
- Eosinophilic pneumonia
Hepatobiliary disorders
- Hepatitis, jaundice
Skin and subcutaneous tissue disorders
- Stevens-Johnson syndrome, drug reaction with eosinophilia and systemic symptoms (DRESS), acute generalised exanthematous pustulosis (AGEP), dermatitis exfoliative, dermatitis bullous, purpura
Renal and urinary disorders
- Renal failure, tubulointerstitial nephritis
Investigations
- Bleeding time prolonged, gamma-glutamyl transferase increased
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