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Sexually Transmitted Infections  |  Chancroid/Genital Ulcers Men

Chancroid/Genital Ulcers Men





Tab Number 5



Single 1000 mg dose

  • ZITHROMAX should be given as a single daily dose1
  • ZITHROMAX tablets and suspension can be taken with or without food1
Renal Impairment1

No dose adjustment is necessary in patients with mild to moderate renal impairment (glomerular filtration rate [GFR] of 10–80 mL/min). Caution should be exercised when ZITHROMAX is administered to patients with severe renal impairment (GFR <10 mL/min)

Hepatic Impairment1

The same dosage as in patients with normal hepatic function may be used in patients with mild to moderate hepatic impairment

GuidelinesAzithromycin: recommended in infection control guidelinesAzithromycin is recommended as a treatment option in the following guidelines: Management of Chancroid2

European Guidelines 2017

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Sexually Transmitted Diseases Treatment Guidelines3

Centers for Disease Control and Prevention (CDC) 2021

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Chancroid prevalence has declined in the United States. When infection occurs, it is commonly associated with sporadic outbreaks3

Worldwide, chancroid appears to have decreased as well, although infection might still occur in certain Africa regions and the Caribbean3

EfficacyZITHROMAX – As effective as ceftriaxone intramuscular (IM) injection when treating chancroid4Comparison of Azithromycin and Ceftriaxone for the Treatment of Chancroid

1st Follow-Up Visit: Oral vs IM

Complete healing of lesions (%)

Adapted from Martin et al. 19954
*not statistically significant

3rd Follow-Up Visit: Oral vs IM

Complete healing of lesions (%)

Adapted from Martin et al. 19954
*not statistically significant

Martin et al. 19954
  • A randomized, unblinded, multicenter, prospective study to determine the efficacy of single-dose azithromycin for the treatment of chancroid
  • At last follow-up visit, all 32 patients whose cultures were positive for Haemophilus ducreyi and treated with azithromycin were clinically cured, and in all 33 culture-positive ceftriaxone-treated cases, there was either clinical improvement or cure
  • A single 1 g oral dose of azithromycin is as effective as a 250 mg IM dose of ceftriaxone for the treatment of chancroid
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Optional footnote area for disclaimers etc.

TitleZITHROMAX is contraindicated in patients with a known hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotic, or to any of the excipients.1
The most recent local resistance data available must always take precedence when selecting antimicrobial therapy; in settings where local resistance data are not available, national and international guidelines can help inform antimicrobial choice.
As with any antibiotic preparation, observation for signs of superinfection with non-susceptible organisms including fungi is recommended. Clostridium difficile associated diarrhea has been reported with azithromycin, and may range in severity from mild diarrhea to fatal colitis.1
The prevalence of acquired resistance to azithromycin may vary geographically and with time for selected species and local information on resistance is desirable, particularly when treating severe infections. Expert advice should be sought when the local prevalence of resistance is such that the utility of azithromycin in at least some types of infections is questionable.1
In patients with severe renal impairment (GFR <10 mL/min), a 33% increase in systemic exposure to ZITHROMAX was observed.1
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Pfizer Malaysia ZITHROMAX Prescribing Information. Available at: Accessed January 2024.Lautenschlager S, et al. Int J STD AIDS. 2017;28(4):324–9.Workowski KA, et al. MMWR Recomm Rep. 2021;70(4):1–192.Martin DH, et al. Clin Infect Dis. 1995;21:409–14.
Sexually Transmitted Infections ZITHROMAX® Safety Information Find out more Loading
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