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Sexually Transmitted Infections  |  Infections by Neisseria gonorrhoeae

Infections by Neisseria
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Risk Factors

Tab Number 5



Single 1000 mg dose

  • ZITHROMAX should be given as a single daily dose1
  • ZITHROMAX tablets and suspension can be taken with or without food1
Renal Impairment1

No dose adjustment is necessary in patients with mild to moderate renal impairment (glomerular filtration rate [GFR] of 10–80 mL/min). Caution should be exercised when ZITHROMAX is administered to patients with severe renal impairment (GFR <10 mL/min)

Hepatic Impairment1

The same dosage as in patients with normal hepatic function may be used in patients with mild to moderate hepatic impairment

GuidelinesAzithromycin: recommended in infection control guidelineAzithromycin is recommended as a treatment option in the following guideline: WHO Guidelines for the Management of Sexually Transmitted Infections2

World Health Organization 2021

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In the US and in the European Union/European Economic Area, gonorrhea is the second most frequently reported bacterial sexually transmitted infection, after Chlamydia trachomatis infection3,4

The Centers for Disease Control and Prevention (CDC) estimates that less than half of all cases are detected and reported5

Risk Factors6
  • Low income
  • Multiple/casual sexual partners
  • Lack of barrier contraception
  • Age at first intercourse
  • According to the Gonococcal Isolate Surveillance Project, Neisseria gonorrhoeae has developed resistance to antibiotics. For example: resistance to penicillin (11.2–13.2%), tetracyclines (16.7–22.8%), and ciprofloxacin (9.6–14.8% ), as reported in 20125
  • There are an estimated 246,000 drug-resistant gonorrhea infections per year in the US (30% of cases), according to the CDC7
ZITHROMAX is contraindicated in patients with a known hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotic, or to any of the excipients.1
The most recent local resistance data available must always take precedence when selecting antimicrobial therapy; in settings where local resistance data are not available, national and international guidelines can help inform antimicrobial choice.
As with any antibiotic preparation, observation for signs of superinfection with non-susceptible organisms including fungi is recommended. Clostridium difficile associated diarrhea has been reported with azithromycin, and may range in severity from mild diarrhea to fatal colitis.1
The prevalence of acquired resistance to azithromycin may vary geographically and with time for selected species and local information on resistance is desirable, particularly when treating severe infections. Expert advice should be sought when the local prevalence of resistance is such that the utility of azithromycin in at least some types of infections is questionable.1
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Resources ZITHROMAX® Mode of Action Find out moreLoadingReferences:Pfizer Malaysia ZITHROMAX Prescribing Information. Available at: Accessed January 2024.World Health Organization. Guidelines for the management of symptomatic sexually transmitted infections. Gevena: 2021. Licence: CC BY-NC-SA 3.0 IGO.Workowski KA, et al. MMWR Recomm Rep. 2021;70(4):1–192.Unemo M, et al. Int J STD AIDS. 2020;0(0). doi: 10.1177/0956462420949126.Kirkcaldy RD, et al. Sex Transm Infect. 2013;89(Suppl. 4):iv5–10.Navarro C, et al. Can J Infect Dis. 2002;13(3):195–207.CDC. Antibiotic Resistance Threats in the United States, 2013. Available at: Accessed June 2023.
Sexually Transmitted Infections ZITHROMAX® Safety Information Find out more Loading
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